HCID 59152920, compound → HCID 59152954, compound

HRID 1645161Notes

Reaction equation

C(OC(=O)CN1C2CCC[C@@H](N([S:17]([C:20]3C=C(C(F)(F)F)C=C(SCC)[CH:21]=3)(=[O:19])=[O:18])C)C=2C=N1)C.[CH2:34]([O:36][C:37](=[O:64])[CH2:38][N:39]1[C:47]2[CH2:46][CH2:45][CH2:44][C@@H:43]([N:48]([S:50]([C:53]3[CH:58]=[C:57]([C:59]([F:62])([F:61])[F:60])[CH:56]=[C:55](F)[CH:54]=3)(=[O:52])=[O:51])[CH3:49])[C:42]=2[CH:41]=[N:40]1)[CH3:35]>>[CH2:34]([O:36][C:37](=[O:64])[CH2:38][N:39]1[C:47]2[CH2:46][CH2:45][CH2:44][C@@H:43]([N:48]([S:50]([C:53]3[CH:58]=[C:57]([C:59]([F:60])([F:61])[F:62])[CH:56]=[C:55]([S:17]([CH2:20][CH3:21])(=[O:19])=[O:18])[CH:54]=3)(=[O:52])=[O:51])[CH3:49])[C:42]=2[CH:41]=[N:40]1)[CH3:35]

Participants

Reactant 2

HCID 59152920HCID 59152920, compound

HCID 59152928HCID 59152928, compound

Product 1

HCID 59152954HCID 59152954, compound

Procedure

Starting with {(R)-4-[(3-ethylsulfanyl-5-trifluoromethyl-benzenesulfonyl)-methyl-amino]-4,5,6,7-tetrahydro-indazol-1-yl}-acetic acid ethyl ester (1st step intermediate of example 8-1) using the method analogous to the one described for example 7-1, {(R)-4-[(3-ethanesulfonyl-5-trifluoromethyl-benzenesulfonyl)-methyl-amino]-4,5,6,7-tetrahydro-indazol-1-yl}-acetic acid ethyl ester was obtained as a white solid. MS cald. for C21H26F3N3O6S2 537, obsd. (ESI+) [(M+H)+] 538.

Sources & evidence

ORD record: ord-225397961ee144eba7abe2a676ad46ed
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08124641B2

Reaction notes

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