(R)-[4-(3-isopropenyl-5-trifluoromethyl-benzenesulfonylamino)-4,5,6,7-tetrahydro-indazol-1-yl]-acetic acid ethyl ester → (R)-[4-(3-isopropyl-5-trifluoromethyl-benzenesulfonylamino)-4,5,6,7-tetrahydro-indazol-1-yl]-acetic acid ethyl ester

Participants

Reaction Steps

A solution of (R)-[4-(3-isopropenyl-5-trifluoromethyl-benzenesulfonylamino)-4,5,6,7-tetrahydro-indazol-1-yl]-acetic acid ethyl ester (using a method analogous to the one described for 1st step intermediate of example 11-1) (34 mg, 0.072 mmol) in methanol was hydrogenated over 10% Pd/C (6 mg) under 30 psi for 3 hours at room temperature. The reaction mixture was filtered through a glass funnel and concentrated to afford (R)-[4-(3-isopropyl-5-trifluoromethyl-benzenesulfonylamino)-4,5,6,7-tetrahydro-indazol-1-yl]-acetic acid ethyl ester (33 mg, 96.8%) as a white solid. MS cald for C21H26F3N3O4S 473, obsd. (ESI+) [(M+H)+] 474.

Provenance & Evidence