Diazomethane → HCID 59152929, compound

HRID 1645167Notes

Reaction equation

HRID 1645167 reaction equation
[CH2:1]([O:3][C:4](=[O:34])[CH2:5][N:6]1[C:14]2[CH2:13][CH2:12][CH2:11][C@@H:10]([N:15]([CH3:33])[S:16]([C:19]3[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[C:21]([C:29](=[CH2:32])[CH2:30][CH3:31])[CH:20]=3)(=[O:18])=[O:17])[C:9]=2[CH:8]=[N:7]1)[CH3:2].[N+](=[CH2:37])=[N-]>C(OCC)C>[CH2:1]([O:3][C:4](=[O:34])[CH2:5][N:6]1[C:14]2[CH2:13][CH2:12][CH2:11][C@@H:10]([N:15]([S:16]([C:19]3[CH:24]=[C:23]([C:25]([F:27])([F:28])[F:26])[CH:22]=[C:21]([C:29]4([CH2:32][CH3:37])[CH2:31][CH2:30]4)[CH:20]=3)(=[O:18])=[O:17])[CH3:33])[C:9]=2[CH:8]=[N:7]1)[CH3:2]

Participants

4

Reactant 2

HCID 9550DiazomethaneHCID 59152946HCID 59152946, compound

Product 1

HCID 59152929HCID 59152929, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Starting with ((R)-4-{methyl-[3-(1-methylene-propyl)-5-trifluoromethyl-benzenesulfonyl]-amino}-4,5,6,7-tetra-hydro-indazol-1-yl)-acetic acid ethyl ester and a solution of diazomethane in diethyl ether using the method analogous to the one described above for 2nd step of example 14-1, ((R)-4-{[3-(1-ethyl-cyclopropyl)-5-trifluoromethyl-benzenesulfonyl]-methyl-amino}-4,5,6,7-tetrahydro-indazol-1-yl)-acetic acid ethyl ester (82 mg, 83%) was obtained as a white solid. MS cald. for C24H30F3N3O4S 513, obsd. (ESI+) [(M+H)+] 514.

Sources & evidence

ORD record
ord-2c1c327099cd4151ba03e54d25971f4c
Source dataset
uspto-grants-2012_02
Patent number
US08124641B2

Reaction notes

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