反应详情

To a solution of 1H-indole-6-carbonitrile (1.00 g, 7.04 mmol) in diethyl ether (50 mL) was added at rt 2-nitrobenzenesulfenyl chloride (1.34 g, 7.04 mmol) and the reaction mixture was stirred for 18 hrs. The mixture was concentrated and the crude product was purified using column chromatography (ethyl acetate/heptane 1:4→4:1) to give 3-(2-Nitro-phenylsulfanyl)-1H-indole-6-carbonitrile (1.62 g, 5.49 mmol, 78%).

1. concentrationThe mixture was concentrated
2. customthe crude product was purified