HCID 66775543, compound → HCID 66775371, compound

Participants

Reaction Steps

To a par bottle charged with benzyl 2-(6-((N-(3-(trifluoromethoxy)benzyl)-1-methyl-1H-imidazole-4-carboxamido)methyl)-3-aza-bicyclo[3.1.0]hexan-3-yl)acetate (2.7 gm, 5.07 mmol) in 80 mL CH3OH, was added 300 mg palladium hydroxide on carbon (20%). The mixture was hydrogenated under 40 psi H2 at room temperature for 1 hour. The mixture was filtered over a celite, the celite pad was washed with CH3OH and the resulting solution was concentrated to yield 2.3 gm of 2-(6-((N-(3-(trifluoromethoxy)benzyl)-1-methyl-1H-imidazole-4-carboxamido)methyl)-3-aza-bicyclo[3.1.0]hexan-3-yl)acetic acid as a yellow solid; 400 MHz 1H NMR (CDCl3) δ 7.54 (s, 1H), 7.23-7.33 (m, 3H), 7.15 (s, 1H), 7.05 (d, J=7.9 Hz, 1H), 5.4 (brs, 2H), 4.81 (brs, 1H), 3.96 (brs, 1H), 3.68 (s, 3H), 3.49 (s, 2H), 3.28 (brs, 1H), 3.12 (brs, 2H), 1.76 (brs, 1H), 1.66 (brs, 2H); MS (M+1) 452.1.

Provenance & Evidence