Methanol → HCID 66775592, compound

Participants

Reaction Steps

62 mg of a sodium methoxide 28% methanol solution was added to a methanol 3 mL solution of 100 mg of 5-(methylsulfonyl)-7-(5-(trifluoromethyl)pyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidine, followed by stirring at room temperature for 5 minutes. After completion of the reaction, water was added to the reaction liquid, followed by extraction with ethyl acetate, the organic layer was dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=1/1) to obtain 85 mg of the desired product.

Provenance & Evidence