Water → HCID 66775561, compound

Participants

Reaction Steps

4.47 g of N-bromosuccinimide and 50 mg of azobisisobutylonitrile (AIBN) were added to a solution having 5.76 g of 7-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-ethyl-[1,2,4]triazolo[1,5-a]pyrimidine dissolved in 30 mL of chloroform, followed by stirring overnight under reflux with heating. After completion of the reaction, water was added to the reaction liquid, followed by extraction with ethyl acetate, the organic layer was dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=5/2) to obtain 4.47 g of the desired product as a solid.

Provenance & Evidence