HCID 58993633, compound → HCID 86635131, compound

Participants

Reaction Steps

Using standard Swern oxidation reaction conditions (see step (v)/Example 80 or step (iii)/Example 81), tert-butyl 4-(hydroxymethyl)-4-(3-(trifluoromethyl)phenyl)piperidine-1-carboxylate (1.2 mmol, 0.43 g) was oxidized to give 1-benzyl-4-(3-(trifluoromethyl)phenyl)piperidine-4-carbaldehyde which was used in the next step without further purification.

Provenance & Evidence