HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → Ethyl 5-(5-formylfuran-2-yl)nicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 5-Bromofuran-2-carbaldehyde | HCID 600328 | — |
| Reactant | Ethyl 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carboxylate | HCID 3816953 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | Ethyl 5-(5-formylfuran-2-yl)nicotinate | HCID 59190169 | 100.2% |
Reaction Steps
A solution of ethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate (570 mg, 2.06 mmol), 5-bromofuran-2-carbaldehyde (300 mg, 1.71 mmol), Cs2CO3 (1.125 g, 3.46 mmol) and PdCl2(dppf) (65 mg, 0.09 mmol) in H2O/dioxane (5%, 10 mL) was heated at reflux for 15 min. The reaction mixture was cooled to rt and diluted with H2O (100 mL). The resulting precipitate was collected by filtration to yield the desired ethyl 5-(5-formylfuran-2-yl)nicotinate (420 mg). LCMS (ES): m/z 246 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124649B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-f59a0ff580b74294aa6c0754a5bc9847 |
| Source note | uspto-grants-2012_02 |