1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 59190116, compound

Participants

Reaction Steps

To a solution of 4-(5-acetylfuran-2-yl)benzoic acid (500 g, 2.17 mmol) and HOBt (587 mg, 4.35 mol) in DMF (5 mL) was added EDCI (835 mg, 4.35 mmol). The reaction was stirred at rt for 10 min and then 1-methylhomopiperazine (1.08 mL, 8.69 mol) was added, followed by DIEA (1.52 mL, 8.69 mmol). The reaction mixture was stirred at rt for 3 h and diluted with H2O (20 mL). The mixture was extracted with DCM (3×25 mL), washed with water (2×25 mL) then brine (25 mL), dried over Na2SO4 and concentrated to give brown oil (800 mg). LCMS (ES): m/z 442 [M+1]+.

Provenance & Evidence