N,N-dimethylformamide N,N-dimethylacetamide → HCID 178517160, compound

Participants

Reaction Steps

3-(5-((5-chloro-2-oxoindolin-3-ylidene)methyl)furan-2-yl)benzamide (100 mg, 0.275 mmol) in 5 mL DMF/DMA was stirred at 80° C. during 2 hr. DMF was evaporated and AcOH (10 mL) added. Hydrazine (1 mL) was added dropwise, the mixture was stirred during 10 minutes at R.T., then 45 minutes at 80° C. Water was added and the solid formed isolated by filtration and dried under vacuum. The product was purified by preparative TLC (DCM/MeOH 1%). LCMS (M+1)=389.

Provenance & Evidence