Acetic Acid → HCID 66771878, compound

Participants

Reaction Steps

Combine 2-(4-methoxy-phenyl)-benzo[b]thiophen-6-ol (10.00 g, 39.01 mmoles), DMAP (478 mg, 3.87 mmoles), and THF (100 mL) under nitrogen and then add triethylamine (4.19 g, 41.03 mmoles) and diethylcarbamoyl chloride (5.73 g, 40.99 mmoles). Heat the mixture to reflux and maintain for 6 hours. Cool the reaction to 50° C. Add a mixture of water (20 mL) and acetic acid (0. 67 mL, 11.68 mmoles). Separate the phases and discard the aqueous phase. This yields a solution of diethyl-carbamic acid 2-(4-methoxy-phenyl)-benzo[b]thiophen-6-yl ester in THF.

Provenance & Evidence