HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-chloro-1-ethyl-1H-indole-2-carboxylic acid → 5-Chloro-1-ethyl-1H-indole-2-carboxylic acid (6-piperazin-1-yl-pyridin-3-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-chloro-1-ethyl-1H-indole-2-carboxylic acid | HCID 15290306 | — |
| Reactant | tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate | HCID 17999304 | — |
| Reactant | 4-Chloro-benzo[b]thiophene-2-carboxylic acid (6-piperazin-1-yl-pyridin-3-yl)-amide | HCID 59365178 | — |
| Product | 5-Chloro-1-ethyl-1H-indole-2-carboxylic acid (6-piperazin-1-yl-pyridin-3-yl)-amide | HCID 59365195 | — |
Reaction Steps
With a method similar to that used for the preparation of 4-chloro-benzo[b]thiophene-2-carboxylic acid (6-piperazin-1-yl-pyridin-3-yl)-amide, 5-chloro-1-ethyl-1,4-indole-2-carboxylic acid (6-piperazin-1-yl-pyridin-3-yl)-amide was prepared from 5-chloro-1-ethyl-1H-indole-2-carboxylic acid and 4-(5-amino-pyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester. LCMS for C20H22Cl N5O calcd. (m/e) 383, observed 384 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124766B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-226e2c9f475c4921b2a85aebddd16e98 |
| Source note | uspto-grants-2012_02 |