4-Chlorobenzo(b)thiophene-2-carboxylic Acid → 4-{5-[(4-Chloro-benzo[b]thiophene-2-carbonyl)-amino]-pyridin-2-yl}-piperazine-1-carboxylic acid tert-butyl ester

HRID 1645345Notes

Reaction equation

HRID 1645345 reaction equation
[Cl:1][C:2]1[C:10]2[CH:9]=[C:8]([C:11]([OH:13])=O)[S:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[NH2:14][C:15]1[CH:16]=[CH:17][C:18]([N:21]2[CH2:26][CH2:25][N:24]([C:27]([OH:29])=[O:28])[CH2:23][CH2:22]2)=[N:19][CH:20]=1>>[C:10]([O:28][C:27]([N:24]1[CH2:25][CH2:26][N:21]([C:18]2[CH:17]=[CH:16][C:15]([NH:14][C:11]([C:8]3[S:7][C:6]4[CH:5]=[CH:4][CH:3]=[C:2]([Cl:1])[C:10]=4[CH:9]=3)=[O:13])=[CH:20][N:19]=2)[CH2:22][CH2:23]1)=[O:29])([CH3:2])([CH3:9])[CH3:6]

Participants

3

Reactant 2

HCID 38545164-Chlorobenzo(b)thiophene-2-carboxylic AcidHCID 574617974-(5-Amino-pyridin-2-yl)-piperazine-1-carboxylic acid

Product 1

HCID 462239524-{5-[(4-Chloro-benzo[b]thiophene-2-carbonyl)-amino]-pyridin-2-yl}-piperazine-1-carboxylic acid tert-butyl ester

Procedure

This compound was prepared from 4-chloro-benzo[b]thiophene-2-carboxylic acid and 4-(5-amino-pyridin-2-yl)-piperazine-1-carboxylic acid tort-butyl ester as described in the preparation of the intermediate section. LCMS for C23H25ClN4O3S calcd. (m/e) 472, observed 471 (M−H).

Workup

  1. customas described in the preparation of the intermediate section

Sources & evidence

ORD record
ord-9ab618bd70a4463ead1aa1846c5859ff
Source dataset
uspto-grants-2012_02
Patent number
US08124766B2

Reaction notes

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