HCID 178462796, compound → HCID 178462795, compound

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A mixture of trans-4-(4-{5-[(1-ethyl-4-methoxy-1H-indole-2-carbonyl)-amino]-pyridin-2-yl}-piperazine-1-carbonyl)-cyclohexanecarboxylic acid benzyl ester (30 mg, 0.05 mmol), 10% Pd/C (50 mg) in methanol (20 mL) was hydrogenated at 50 psi for 2 hr. The solution was filtered and the solvent was removed to afford the product, trans-4-(4-{5-[(1-ethyl-4-methoxy-1H-indole-2-carbonyl)-amino]-pyridin-2-yl}-piperazine-1-carbonyl)-cyclohexane carboxylic acid, as a green solid (10 mg, 40% yield). LCMS for C29H35N5O5 calcd. (m/e) 533, observed 534 (M+H).

Provenance & Evidence