HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-chloro-1-ethyl-1H-indole-2-carboxylic acid → 5-Chloro-1-ethyl-4H-indole-2-carboxylic acid {6-[(2-methoxy-ethyl)-methyl-amino]-pyridin-3-yl}-amide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-chloro-1-ethyl-1H-indole-2-carboxylic acid | HCID 15290306 | — |
| Reactant | 1-ethyl-5-trifluoromethoxy-1H-indole-2-carboxylic acid {6-[(2-methoxy-ethyl)-methyl-amino]-pyridin-3-yl}-amide hydrochloride | HCID 66772408 | — |
| Reactant | 5-chloro-1-ethyl-1H-indole-2-carboxylic acid {6-[(2-methoxy-ethyl)-methyl-amino]-pyridin-3-yl}-amide hydrochloride | HCID 66772765 | — |
| Product | 5-Chloro-1-ethyl-4H-indole-2-carboxylic acid {6-[(2-methoxy-ethyl)-methyl-amino]-pyridin-3-yl}-amide hydrochloride | HCID 86642414 | — |
Reaction Steps
With a method similar to that used for the preparation of 1-ethyl-5-trifluoromethoxy-1H-indole-2-carboxylic acid {6-[(2-methoxy-ethyl)-methyl-amino]-pyridin-3-yl}-amide hydrochloride, 5-chloro-1-ethyl-1H-indole-2-carboxylic acid {6-[(2-methoxy-ethyl)-methyl-amino]-pyridin-3-yl}-amide hydrochloride was prepared from 5-chloro-1-ethyl-1H-indole-2-carboxylic acid. LCMS for C20H23ClN4O2 calcd. (m/e) 386, observed 387 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124766B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-cd84c83f71b24d27bc3ca414dd77facb |
| Source note | uspto-grants-2012_02 |