4-(4-{5-[(4-Chloro-benzo[b]thiophene-2-carbonyl)-amino]-pyridin-2-yl}-piperazin-1-yl)-2,2-dimethyl-4-oxo-butyric acid → 4-(4-{4-[(4-Ethoxy-1-ethyl-1H-indole-2-carbonyl)-amino]-phenyl}-piperazin-1-yl)-2,2-dimethyl-4-oxo-butyric acid

関与物質

反応手順

With a method similar to that used for the preparation of 4-(4-{5-[(4-chloro-benzo[b]thiophene-2-carbonyl)-amino]-pyridin-2-yl}-piperazin-1-yl)-2,2-dimethyl-4-oxo-butyric acid, 4-(4-{4-[(4-ethoxy-1-ethyl-1,1-indole-2-carbonyl)-amino]-phenyl}-piperazin-1-yl)-2,2-dimethyl-4-oxo-butyric acid was prepared from 4-ethoxy-1-ethyl-1H-indole-2-carboxylic acid (4-piperazin-4-yl-phenyl)-amide. LCMS for C29H36N4O5 calcd. (m/e) 520, observed 521 (M+H).

情報源と証拠