HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-1-ethyl-indole-2-carboxylic acid → (S)-3-{5-[(5-Bromo-1-ethyl-1H-indole-2-carbonyl)-amino]-pyridin-2-ylamino}-pyrrolidine-1-carboxylic acid ethyl ester hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-1-ethyl-indole-2-carboxylic acid | HCID 52911008 | — |
| Reactant | (S)-3-(5-amino-pyridin-2-ylamino)-pyrrolidine-1-carboxylic acid ethyl ester | HCID 59365133 | — |
| Reactant | (S)-3-{5-[(5-bromo-benzo[b]thiophene-2-carbonyl)-amino]-pyridin-2-ylamino}-pyrrolidine-1-carboxylic acid ethyl ester hydrochloride | HCID 66772122 | — |
| Product | (S)-3-{5-[(5-Bromo-1-ethyl-1H-indole-2-carbonyl)-amino]-pyridin-2-ylamino}-pyrrolidine-1-carboxylic acid ethyl ester hydrochloride | HCID 66772560 | — |
Reaction Steps
With a method similar to that used for the preparation of (S)-3-{5-[(5-bromo-benzo[b]thiophene-2-carbonyl)-amino]-pyridin-2-ylamino}-pyrrolidine-1-carboxylic acid ethyl ester hydrochloride, (S)-3-{5-[(5-bromo-1-ethyl-1,4-indole-2-carbonyl)-amino]-pyridin-2-ylamino}-pyrrolidine-1-carboxylic acid ethyl ester hydrochloride was prepared from (S)-3-(5-amino-pyridin-2-ylamino)-pyrrolidine-1-carboxylic acid ethyl ester and 5-bromo-1-ethyl-indole-2-carboxylic acid. LCMS for C23H26BrN5O3 calcd. (m/e) 499, observed 500 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124766B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-fa719a9111a34d30b69d35cb7dccccec |
| Source note | uspto-grants-2012_02 |