2-oxaspiro[4.4]nonane-1,3-dione → 1-[2-(4-{4-[(4,5-Dichloro-1-ethyl-1H-indole-2-carbonyl)-amino]-phenyl}-piperidin-1-yl)-2-oxo-ethyl]-cyclopentanecarboxylic acid

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Reaction Steps

With a method similar to that used for the preparation of 4-(4-{4-[(4-ethoxy-1-ethyl-1H-indole-2-carbonyl)-amino]-phenyl}-piperidin-1-yl)-2,2-dimethyl-4-oxo-butyric acid, 1-[2-(4-{4-[(4,5-dichloro-1-ethyl-1H-indole-2-carbonyl)-amino]-phenyl}1-piperidin-1-yl)-2-oxo-ethyl]cyclopentanecarboxylic acid was prepared from 4,5-dichloro-1-ethyl-1H-indole-2-carboxylic acid (4-piperidin-4-yl-phenyl)-amide and 2-oxa-spiro[4,4]nonane-1,3-dione. LCMS for C30H33Cl2N3O4 calcd. (m/e) 569, observed 570 (M+H).

Provenance & Evidence