2,4-Dioxo-5-thiazolidineacetic acid → 4,5-Dichloro-1-ethyl-1H-indole-2-carboxylic acid (4-{4-[2-(2,4-dioxo-thiazolidin-5-yl)-acetyl]-piperazin-1-yl}-phenyl)-amide

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With a method similar to that used for the preparation of 4-ethoxy-1-ethyl-1H-indole-2-carboxylic acid (4-{4-[2-(2,4-dioxo-thiazolidin-5-yl)-acetyl]-piperazin-1-yl}-phenyl)-amide hydrochloride, 4,5-dichloro-1-ethyl-1,1-indole-2-carboxylic acid (4-{4-[2-(2,4-dioxo-thiazolidin-5-yl)-acetyl]-piperazin-1-yl}-phenyl)-amide was prepared from 4,5-dichloro-1-ethyl-1H-indole-2-carboxylic acid (4-piperazin-1-yl-phenyl)-amide and (2,4-dioxo-thiazolidin-5-yl)-acetic acid. LCMS for C26H25Cl2N5O4S calcd. (m/e) 573, observed 574 (M+H).

Provenance & Evidence