6,7-Diethoxy-3-methyl-1-benzofuran-2-carboxylic acid → 4-{4-[(6,7-Diethoxy-3-methyl-benzofuran-2-carbonyl)-amino]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

HRID 1645368Notes

Reaction equation

HRID 1645368 reaction equation
[CH2:1]([O:3][C:4]1[CH:16]=[CH:15][C:7]2[C:8]([CH3:14])=[C:9]([C:11]([OH:13])=O)[O:10][C:6]=2[C:5]=1[O:17][CH2:18][CH3:19])[CH3:2].[C:20]([O:24][C:25]([N:27]1[CH2:32][CH2:31][N:30]([C:33]2[CH:38]=[CH:37][C:36]([NH2:39])=[CH:35][CH:34]=2)[CH2:29][CH2:28]1)=[O:26])([CH3:23])([CH3:22])[CH3:21]>>[C:20]([O:24][C:25]([N:27]1[CH2:32][CH2:31][N:30]([C:33]2[CH:34]=[CH:35][C:36]([NH:39][C:11]([C:9]3[O:10][C:6]4[C:5]([O:17][CH2:18][CH3:19])=[C:4]([O:3][CH2:1][CH3:2])[CH:16]=[CH:15][C:7]=4[C:8]=3[CH3:14])=[O:13])=[CH:37][CH:38]=2)[CH2:29][CH2:28]1)=[O:26])([CH3:23])([CH3:21])[CH3:22]

Participants

3

Reactant 2

HCID 7447606,7-Diethoxy-3-methyl-1-benzofuran-2-carboxylic acidHCID 11011301tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate

Product 1

HCID 593651744-{4-[(6,7-Diethoxy-3-methyl-benzofuran-2-carbonyl)-amino]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

Procedure

With a procedure similar to the example above, 4-{4-[(6,7-diethoxy-3-methyl-benzofuran-2-carbonyl)-amino]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester was prepared from 6,7-diethoxy-3-methyl-benzofuran-2-carboxylic acid and 4-(4-amino-phenyl)-piperazine-1-carboxylic acid tert-butyl ester. LCMS calcd for C29H37N3O6 (m/e) 523, obsd 524 (M+H).

Sources & evidence

ORD record
ord-a04f24e423214d3cbf77f4f46e6eee01
Source dataset
uspto-grants-2012_02
Patent number
US08124766B2

Reaction notes

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