Dimethylformamide → 2-Bromo-5-[(propan-2-yl)oxy]pyridine

Participants

Reaction Conditions

Reaction Steps

2-Bromopropane (1.13 mL, 12 mmol) and potassium carbonate (1.43 g, 10.4 mmol) were added in that order to a DMF (10 mL) solution of 6-bromopyridin-3-ol (1 g, 5.75 mmol), and stirred at 80° C. for 2 hours. The temperature of the solution was restored to room temperature, then this was diluted with ethyl acetate, washed twice with distilled water and once with saturated brine. The organic layer was dried with magnesium sulfate and concentrated under reduced pressure to give the intended product (1.28 g, 100%).

Provenance & Evidence