HCID 57583245, compound → HCID 57583271, compound

HRID 1645499Notes

Reaction equation

HRID 1645499 reaction equation
[CH2:1]([N:8](C)[CH2:9][CH2:10][CH:11]([CH2:24][N:25](CC1C=CC=CC=1)[CH3:26])[CH2:12][CH2:13][CH2:14][N:15](CC1C=CC=CC=1)[CH3:16])C1C=CC=CC=1.[H][H]>[Pd]>[CH3:1][NH:8][CH2:9][CH2:10][CH:11]([CH2:24][NH:25][CH3:26])[CH2:12][CH2:13][CH2:14][NH:15][CH3:16]

Participants

4

Reactant 2

HCID 57583245HCID 57583245, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 57583271HCID 57583271, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

To a methanolic solution of N1,N6-Dibenzyl-3-[(benzyl-methyl-amino)-methyl]-N1,N6-dimethylhexane-1,6-diamine (1 g, 0.002 mol) was added 1 g of Pd/C. The solution was exposed to 2 bar of hydrogen and left to shake for 48 hours at ambient temperature. The reaction mixture was filtered through celite and concentrated at reduced pressure to yield a viscous oil. The structure was confirmed by NMR, yield ˜90%.

Workup

  1. waitleft
  2. filtrationThe reaction mixture was filtered through celite
  3. concentrationconcentrated at reduced pressure
  4. customto yield a viscous oil

Sources & evidence

ORD record
ord-bfefebd5575f43ba94aafc55c2774683
Source dataset
uspto-grants-2012_02
Patent number
US08124806B2

Reaction notes

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