HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclobutanone → 2-(((4-(5,9-Dioxaspiro[3.5]non-7-ylmethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclobutanone | HCID 14496 | — |
| Reactant | Trimethylolmethane | HCID 78432 | — |
| Reactant | 2-(((4-(6,10-Dioxaspiro[4.5]dec-8-ylmethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt | HCID 66776670 | — |
| Product | 2-(((4-(5,9-Dioxaspiro[3.5]non-7-ylmethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt | HCID 66776535 | 6.2% |
Reaction Steps
The same procedure as in the steps (21a) and (21b) of Example 21 was repeated using 2-(hydroxymethyl)-1,3-propanediol and cyclobutanone to obtain the title compound (265 mg, total yield: 6.2%) as a light yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124780B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-a1e0e021a5ed4677aa71c30b14bcfed1 |
| Source note | uspto-grants-2012_02 |