Cyclohexanone → 1,5-Dioxaspiro[5.5]undec-3-ylmethanol

HRID 1645577Notes

Reaction equation

[OH:1][CH2:2][CH:3]([CH2:6][OH:7])[CH2:4][OH:5].[C:8]1(=O)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1>>[O:1]1[C:8]2([CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)[O:5][CH2:4][CH:3]([CH2:6][OH:7])[CH2:2]1

Participants

Reactant 2

HCID 7967Cyclohexanone

HCID 78432Trimethylolmethane

Product 1

HCID 152866931,5-Dioxaspiro[5.5]undec-3-ylmethanolYield 65%

Procedure

The same procedure as in the step (1a) of Example 1 was repeated using 2-(hydroxymethyl)-1,3-propanediol and cyclohexanone to obtain the title compound (2.26 g, yield: 65%) as a light yellow oil.

Sources & evidence

ORD record: ord-f87f028f6a9c4972a1c56178531d326f
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08124780B2

Reaction notes

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