2-(2-Methyl-1,3-dioxan-2-yl)ethanol → 2-(((3-Methyl-4-(2-(2-methyl-1,3-dioxan-2-yl)ethoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

HRID 1645584Notes

Reaction equation

HRID 1645584 reaction equation
[Na:1].[CH3:2][C:3]1[C:4]([CH2:21][S:22]([C:24]2[NH:28][C:27]3[CH:29]=[CH:30][CH:31]=[CH:32][C:26]=3[N:25]=2)=[O:23])=[N:5][CH:6]=[CH:7][C:8]=1[O:9][CH2:10][CH2:11][C:12]1([CH2:18]CC)[O:17][CH2:16][CH2:15][CH2:14][O:13]1.CC1(CCO)OCCCO1>>[Na:1].[CH3:2][C:3]1[C:4]([CH2:21][S:22]([C:24]2[NH:25][C:26]3[CH:32]=[CH:31][CH:30]=[CH:29][C:27]=3[N:28]=2)=[O:23])=[N:5][CH:6]=[CH:7][C:8]=1[O:9][CH2:10][CH2:11][C:12]1([CH3:18])[O:17][CH2:16][CH2:15][CH2:14][O:13]1

Participants

3

Reactant 2

HCID 596567682-(2-Methyl-1,3-dioxan-2-yl)ethanolHCID 667766942-(((3-Methyl-4-(2-(2-propyl-1,3-dioxan-2-yl)ethoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

Product 1

HCID 667764232-(((3-Methyl-4-(2-(2-methyl-1,3-dioxan-2-yl)ethoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium saltYield 2.5%

Procedure

The same procedure as in the steps (8c) to (8g) of Example 8, was repeated using 2-(2-methyl-1,3-dioxan-2-yl)ethanol obtained in the step (30a) to obtain the title compound (113 mg, total yield: 2.5%) as a light yellow solid.

Workup

  1. customobtained in the step (30a)

Sources & evidence

ORD record
ord-26eaffb65d2a49ea94316131eea548f2
Source dataset
uspto-grants-2012_02
Patent number
US08124780B2

Reaction notes

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