HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-2,3-dimethyl-1-oxidopyridin-1-ium → 2-(((4-((2-(Fluoromethyl)-1,3-dioxolan-2-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-2,3-dimethyl-1-oxidopyridin-1-ium | HCID 9877446 | — |
| Reactant | (2-(Fluoromethyl)-1,3-dioxolan-2-yl)methanol | HCID 59792379 | — |
| Reactant | 2-(((3-Methyl-4-(2-(2-propyl-1,3-dioxolan-2-yl)ethoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt | HCID 66775818 | — |
| Product | 2-(((4-((2-(Fluoromethyl)-1,3-dioxolan-2-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt | HCID 66776486 | 8.2% |
Reaction Steps
The same procedure as in the steps (3c) to (3h) of Example 3 was repeated using 4-chloro-2,3-dimethylpyridine 1-oxide and (2-(fluoromethyl)-1,3-dioxolan-2-yl)methanol to obtain the title compound (140 mg, 6 steps 8.2%) as a light yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124780B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-1108999acf204aff9c71dce23ace5e74 |
| Source note | uspto-grants-2012_02 |