1,3-Dioxane, 5,5-difluoro-2-[(phenylmethoxy)methyl]- → (5,5-Difluoro-1,3-dioxan-2-yl)methanol

Participants

Reaction Steps

A mixture of 2-((benzyloxy)methyl)-5,5-difluoro-1,3-dioxane (930 mg, 3.81 mmol), 20% palladium hydroxide (353 mg), and ethyl acetate (30 ml) was stirred in a hydrogen atmosphere at room temperature for 4 hours and 25 minutes. The reaction mixture was filtrated and the filtrate was concentrated under reduced pressure to obtain the title compound (572 mg, 97.4%) as a colorless oil.

Provenance & Evidence