Carbon Disulfide → HCID 178505474, compound

HRID 1645624Notes

Reaction equation

HRID 1645624 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([F:9])[CH:5]=[CH:6][C:7]=1[NH2:8].[C:10](=S)=[S:11]>CO>[F:9][C:4]1[CH:5]=[CH:6][C:7]2[NH:8][C:10]([SH:11])=[N:1][C:2]=2[CH:3]=1

Participants

4

Reactant 2

HCID 6348Carbon DisulfideHCID 1645844-Fluorobenzene-1,2-diamine

Product 1

HCID 178505474HCID 178505474, compoundYield 98.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 3,4-diamino-1-fluorobenzene (10 g, 79.3 mmol), carbon disulfide (70 ml, 1164 mmol), and methanol (100 ml) was stirred at room temperature for 86 hours and 50 minutes. After the reaction mixture was concentrated, the residue was suspended in hexane. The resultant precipitate was collected by filtration and washed with hexane to obtain the title compound (13.1 g, yield: 98.2%) as a brown solid.

Workup

  1. concentrationAfter the reaction mixture was concentrated
  2. filtrationThe resultant precipitate was collected by filtration
  3. washwashed with hexane

Sources & evidence

ORD record
ord-81a6f07e50994ccbb979f5b148948928
Source dataset
uspto-grants-2012_02
Patent number
US08124780B2

Reaction notes

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