HuagongsheHuagongshe Chemistry Print Report · For research reference only
Solketal → HCID 178431368, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Solketal | HCID 7528 | — |
| Reactant | 4-Chloro-2,3-dimethyl-1-oxidopyridin-1-ium | HCID 9877446 | — |
| Reactant | 2-(((4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt | HCID 66775847 | — |
| Reactant | HCID 178505474 | HCID 178505474 | — |
| Product | HCID 178431368 | HCID 178431368 | 14.1% |
Reaction Steps
The same procedure as in the step (10b) of Example 10 and the step (14b) of Example 14, the step (5f) of Example 5, the steps (11h) and (11i) of Example 11 was repeated using solketal, 4-chloro-2,3-dimethylpyridine 1-oxide, and 5-fluoro-1H-benzimidazole-2-thiol to obtain the title compound (210 mg, yield: 14.1%) as a white solid. Note that methanol was used as a solvent instead of ethanol in the same operation as in the step (5f).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124780B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-ff6610614c054fd3bb2a3f0cc5d2356c |
| Source note | uspto-grants-2012_02 |