HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Chloroperbenzoic acid → 2-(((4-(2-(9-Methyl-1,5,8,10-tetraoxaspiro[5.5]undec-9-yl)ethoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | 2-(9-Methyl-1,5,8,10-tetraoxaspiro[5.5]undec-9-yl)ethanol | HCID 59792508 | — |
| Reactant | 2-(((3-Methyl-4-((8-methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)methoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt | HCID 66776550 | — |
| Product | 2-(((4-(2-(9-Methyl-1,5,8,10-tetraoxaspiro[5.5]undec-9-yl)ethoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt | HCID 66776265 | 11.4% |
Reaction Steps
The same procedure as in the steps (5d) to (5h) of Example 5 (a reprecipitation operation was not performed in oxidation step with 3-chloroperbenzoic acid) was repeated using 2-(9-methyl-1,5,8,10-tetraoxaspiro[5.5]undec-9-yl)ethanol obtained in the step (76d) above to obtain the title compound (228 mg, total 11.4% yield) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124780B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-1d80a0f853494b69afb162bbe75e80c3 |
| Source note | uspto-grants-2012_02 |