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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1645663Generated: October 26, 2026

2-(((4-((2-methoxy-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole → 2-(((4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3-ethylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

https://huagongshe.com/reaction/1645663

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(((4-((2-methoxy-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazoleHCID 12003120—
Reactant(4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3-ethylpyridin-2-yl)methanolHCID 59792593—
Reactant2-(((4-((2-Methoxy-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium saltHCID 66776002—
Product2-(((4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3-ethylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium saltHCID 6677572325%

Reaction Steps

The same procedure as in the steps (6d), (6e), and (6f) of Example 6 was repeated using the (4-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-3-ethylpyridin-2-yl)methanol obtained in the step (92d) above to obtain the title compound (159 mg, overall yield: 25%) as a light yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08124780B2
Source datasetuspto-grants-2012_02
ORD IDord-b1acebd18e32480b8da5cc5b3dafd1d4
Source noteuspto-grants-2012_02