HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-(5,7-Dioxaspiro[2.5]oct-6-ylmethoxy)-3-methylpyridin-2-yl)methanol → 2-(((4-(5,7-Dioxaspiro[2.5]oct-6-ylmethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-6,7-dihydro-1h-[1,4]dioxino[2,3-f]benzimidazole sodium salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-(5,7-Dioxaspiro[2.5]oct-6-ylmethoxy)-3-methylpyridin-2-yl)methanol | HCID 59792562 | — |
| Reactant | 2-(((3-Methyl-4-((8-methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)methoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt | HCID 66776550 | — |
| Reactant | HCID 178527752 | HCID 178527752 | — |
| Product | 2-(((4-(5,7-Dioxaspiro[2.5]oct-6-ylmethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-6,7-dihydro-1h-[1,4]dioxino[2,3-f]benzimidazole sodium salt | HCID 66776693 | 55.6% |
Reaction Steps
The same procedure as in the steps (5f) to (5h) was repeated using the (4-(5,7-dioxaspiro[2.5]oct-6-ylmethoxy)-3-methylpyridin-2-yl)methanol obtained in Example (2d) and 6,7-dihydro-1H-[1,4]dioxino[2′,3′:4,5]benzo[d]imidazole-2-thiol to obtain the title compound (364 mg, total 55.6% yield) as a light pink solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124780B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-ed73e8d4006e4242a35c9ef3897e424f |
| Source note | uspto-grants-2012_02 |