反应详情

温度

85 °C

4-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-2,3,5-trimethylpyridine 1-oxide (10.5 g, 37.4 mmol) was dissolved in acetic anhydride (100 mL) and the solution was stirred at 85° C. for 1.5 hours. After the reaction mixture was concentrated, the residue was purified by silica gel column chromatography (elution solvent: n-heptane/ethyl acetate=1/1→0/1) and a desired fraction was concentrated to obtain the title compound (6.1 g, 50.4%) as a light yellow solid.

1. concentrationAfter the reaction mixture was concentrated
2. customthe residue was purified by silica gel column chromatography (elution solvent: n-heptane/ethyl acetate=1/1→0/1)
3. concentrationa desired fraction was concentrated