Sodium Hydroxide → HCID 44612507, compound

Participants

Reaction Steps

Compound 3-{2-[4-(2-amino-phenylcarbamoyl)-phenylamino]-pyrimidin-4-yl}-2-methyl-imidazo[1,2-a]pyridine-7-carboxylic acid methyl ester (200 mg, 0.4 mmol) was dissolved in MeOH (5 mL) and then treated with 1N NaOH (1 mL). After 2 hours the reaction mixture was evaporated and the solids were re-suspended in water and 1N HCl was slowly added to precipitate the title compound. MS found for C26H21N7O3 as (M+H)+ 480.53. 1H NMR (400 MHz, dmso-d6): δ 9.99 (s, 1H), 9.72 (d, J=5.6 Hz, 1H), 9.47 (s, 1H), 8.59 (d, J=5.5 Hz, 1H), 8.07 (s, 1H), 7.90-7.84 (m, 4H), 7.39 (dd, J=7.2, 6.0 Hz, 1H), 7.18-7.09 (m, 2H), 6.90 (t, J=6.0 Hz, 1H), 6.72 (d, J=7.6 Hz, 1H), 6.56-6.48 (m, 1H), 2.64 (s, 3H).

Provenance & Evidence