Benzyl Alcohol → HCID 19802321, compound

Participants

Reaction Steps

To a solution of 2-(2-naphthylthiomethyl)glutaric acid (14.0 g) in acetonitrile (180 ml) was added benzyl alcohol (57 ml) followed by p-toluenesulfonic acid (0.52 g), and the mixture was refluxed for 23 hours. The reaction mixture was concentrated in vacuo, and the resulting residue was purified by flash column chromatography on silica eluting with dichloromethane/methanol (70:1), and recrystallized from ethyl acetate-hexane to give 11.0 g of 2-(2-benzyloxycarbonylethyl)-3-(2-naphthylthio)propionic acid.

Provenance & Evidence