HCID 10531324, compound → HCID 10601170, compound

Participants

Reaction Steps

To a solution of benzyl 4-(N-ethoxycarbonylmethyl-N-pentylcarbamoyl)-5-(2-naphthylsulfonyl)pentanoate (200 mg) in ethanol (10 ml) was added 10% Pd-C (20 mg), and the mixture was hydrogenolyzed at atmospheric pressure for 60 hours. After the catalyst was filtered off, the filtrate was concentrated in vacuo. The residue was purified by flash column chromatography on silica eluting with chloroform/methanol (10:1), and recrystallized from isopropyl ether-hexane to give 170 mg of 4-(N-ethoxycarbonylmethyl-N-pentylcarbamoyl)-5-(2-naphthylsulfonyl)pentanoic acid.

Provenance & Evidence