HCID 9956704, compound → HCID 178446367, compound

HRID 1645795Notes

Reaction equation

[CH3:1][O:2][CH2:3][CH2:4][CH2:5][N:6]([CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[C:7]([CH:9]([CH2:15][S:16]([C:19]1[CH:28]=[CH:27][C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=1)(=[O:18])=[O:17])[CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[O:8].[NH2:34][C@H:35]([C:43]([OH:45])=[O:44])[CH2:36][CH2:37][CH2:38][NH:39][C:40](=[NH:42])[NH2:41]>C(O)C.O>[OH2:2].[CH3:1][O:2][CH2:3][CH2:4][CH2:5][N:6]([CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[C:7]([CH:9]([CH2:15][S:16]([C:19]1[CH:28]=[CH:27][C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=1)(=[O:17])=[O:18])[CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[O:8].[NH2:34][C@H:35]([C:43]([OH:45])=[O:44])[CH2:36][CH2:37][CH2:38][NH:39][C:40](=[NH:41])[NH2:42]

Participants

Conditions

Temperature: 40 °C

Procedure

In a solution of ethanol (19.5 ml) and water (1.2 ml) was dissolved (-)-4-[N-(3-methoxypropyl)-N-pentylcarbamoyl]-5-(2-naphthylsulfonyl)pentanoic acid (7.80 g) and L-arginine (2.84 g) with stirring at 40° C. Insoluble materials (e.g. trash) were collected by filtration and washed with a mixture of ethanol (7 ml) and water (1.3 ml). After combining the filtrate and washing, the mixture was allowed to stand at room temperature, and the precipitated crystals were collected by filtration to obtain 9.80 g of L-arginine (-)-4-[N-(3-methoxypropyl)-N-pentylcarbamoyl]-5-(2-naphthylsulfonyl)pentanoic acid monohydrate.

Workup

filtrationInsoluble materials (e.g. trash) were collected by filtration
washwashed with a mixture of ethanol (7 ml) and water (1.3 ml)
washwashing
customto stand at room temperature
filtrationthe precipitated crystals were collected by filtration

Sources & evidence

ORD record: ord-90bfc5007a644f338e3d75f3412f9c95
Source dataset: uspto-grants-1993_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05177069

Reaction notes

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