4-[(2-Amino-6-chloropyrimidin-4-yl)amino]benzonitrile → 4-[(2-Amino-6-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]amino}-pyrimidin-4-yl)amino]benzonitrile

Participants

Role	Name	HCID	Charge
Reactant	4-[(2-Amino-6-chloropyrimidin-4-yl)amino]benzonitrile	HCID 240806	—
Reactant	4-((1H-Pyrrolo[2,3-B]pyridin-4-YL)oxy)-3-fluoroaniline	HCID 16037965	—
Product	4-[(2-Amino-6-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]amino}-pyrimidin-4-yl)amino]benzonitrile	HCID 17979293	—

Reaction Steps

Analogously to example 25, the title compound is synthesized from 51 mg (0.21 mmol) of [3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]amine (from example XIX) and 54 mg (0.22 mmol) of 4-[(2-amino-6-chloropyrimidin-4-yl)amino]benzonitrile (from example XLVII). Purification by preparative HPLC gives the product.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07737153B2
Source dataset	uspto-grants-2010_06
ORD ID	ord-a970582485954ea6b2c103c6a237904d
Source note	uspto-grants-2010_06