Potassium Carbonate → HCID 86746446, compound

Participants

Reaction Steps

3.0 g (0.022 mol) potassium carbonate were added to a stirred solution of 1.5 g (0.006 mol) 4-(3-phenylpropyl)-1-piperazineethanol (GB Pat. No. 1545094) and 2.41 g (0.010 mol) (4-fluorophenyl)(3-methyl-2-thienyl)methyl chloride (e.g. German patent appl. DE 3726068) in 50 ml acetone. The mixture was refluxed for 2 h, then cooled and diluted with toluene (100 ml). The solution was washed twice with water and once with brine. Evaporation of the organic layer in vacuo yielded an oil, which was redissolved in 50 ml acetonitrile and treated with a solution of maleic acid in acetonitrile. The precipitate was filtered off, washed with diethylether and dried. Recrystallization from ethanol gave 2.88 g (70% of theoretical yield) of the title compound as the dimaleate salt, white solid, m.p. 146°-47° C.

Provenance & Evidence