Potassium Carbonate → HCID 4742804, compound

Participants

Reaction Steps

A mixture of 1.1 g (0.0044 mol) 4-(3-phenylpropyl)-1-piperazine-ethanol, 1.0 g (0.0044 mol)(4-fluorophenyl)-(3-thienyl)methyl chloride (as prepared in step A), 1.22 g (0.0088 mol) potassium carbonate and 50 ml toluene was stirred and heated to reflux for 16 h. The reaction mixture was cooled, diluted with toluene and washed with water. The toluene layer was then extracted with 10% tartaric acid. The aqueous phase was separated and rendered basic by addition of 4N sodium hydroxide in excess and extracted with toluene. Evaporation gave the crude product as an oil, which was purified on a silica column (eluent was toluene/ethanol 2:1). The pure fraction was evaporated, redissolved in diethyl ether and treated with a solution of hydrogen chloride in ether. The precipitate was filtered off and recrystallized from isopropanol. The yield was 0.265 g (=12%) of the title compound as the dihydrochloride. M.p. 212°-15° C.

Provenance & Evidence