Lithium Hydroxide → HCID 21840857, compound

Participants

Reaction Steps

A suspension of 98.4 g of [3S] 3,4-dihydro-6,7-dimethoxy-3-[(3,5-dimethoxybenzoyloxy)methyl]-1-(3,5-dimethoxyphenyl)-isoquinoline [Formula IIa: all of R1 to R4 =methoxy], 51 CH3OH and 207 ml aqueous lithium hydroxide, is stirred for 12 hrs. at room temperature. The obtained solution is concentrated under reduced pressure, treated with ethyl acetate and washed with H2O/Na2CO3. The organic phase is dried over K2CO3 and the solvent removed under reduced pressure. The residue is taken up in ethyl ether, crystallized, filtered and dried to yield the title compound: m.p.=59°-62° C., αD20 =-55.19° (c=0.5 in CH3OH).

Provenance & Evidence