4-((1H-Pyrrolo[2,3-B]pyridin-4-YL)oxy)-3-fluoroaniline → HCID 58733266, compound

HRID 16459Notes

Reaction equation

HRID 16459 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[O:9][C:10]1[CH:15]=[CH:14][N:13]=[C:12]2[NH:16][CH:17]=[CH:18][C:11]=12)[NH2:5].[CH2:19]([O:21][C:22](=[O:32])[CH2:23][C:24]1[CH:29]=[C:28](Cl)[N:27]=[C:26]([NH2:31])[N:25]=1)[CH3:20]>>[CH2:19]([O:21][C:22](=[O:32])[CH2:23][C:24]1[CH:29]=[C:28]([NH:5][C:4]2[CH:6]=[CH:7][C:8]([O:9][C:10]3[CH:15]=[CH:14][N:13]=[C:12]4[NH:16][CH:17]=[CH:18][C:11]=34)=[C:2]([F:1])[CH:3]=2)[N:27]=[C:26]([NH2:31])[N:25]=1)[CH3:20]

Participants

3

Reactant 2

HCID 160379654-((1H-Pyrrolo[2,3-B]pyridin-4-YL)oxy)-3-fluoroanilineHCID 58733357HCID 58733357, compound

Product 1

HCID 58733266HCID 58733266, compound

Procedure

The title compound is synthesized analogously to example 25 from 220 mg (0.908 mmol) of 3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline (from example XIX) and 195 mg (0.908 mmol) of ethyl(2-amino-6-chloropyrimidin-4-yl)acetate (from example LXIX).

Sources & evidence

ORD record
ord-55873feb4ed9479fa4f77b9b6aef22e1
Source dataset
uspto-grants-2010_06
Patent number
US07737153B2

Reaction notes

Loading…