Acetic Anhydride → HCID 19802530, compound

HRID 1645903Notes

Reaction equation

HRID 1645903 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][NH:6][C:7]2=[O:12].[C:13](OC(=O)C)(=[O:15])[CH3:14]>>[O:12]=[C:7]1[C:8]2[C:3](=[C:2]([NH:1][C:13](=[O:15])[CH3:14])[CH:11]=[CH:10][CH:9]=2)[CH2:4][CH2:5][NH:6]1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 183695095-Amino-3,4-dihydro-1(2H)-isoquinolinone

Product 1

HCID 19802530HCID 19802530, compoundYield 56%

Procedure

To 1.0 g (6.17 mmol) of 5-amino-3,4-dihydro-1(2H)-isoquinolinone was added 3 ml of acetic anhydride and the solution was warmed on a steam bath for one hour. It was poured into ice water and heated on a steam bath until all material dissolved. The solution was allowed to cool, the solid was collected, washed with water, and dried to give 0.7 g (56%) of product; mp 244°-246°.

Workup

  1. temperaturethe solution was warmed on a steam bath for one hour
  2. temperatureheated on a steam bath until all material
  3. dissolutiondissolved
  4. temperatureto cool
  5. customthe solid was collected
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-a3761327c4894b098c6e95d135f773ca
Source dataset
uspto-grants-1993_01
Patent number
US05177075

Reaction notes

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