HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 4-Bromo-5-methylisoquinolin-1(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 5-Methyl-1,2-dihydroisoquinolin-1-one | HCID 9920450 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Bromo-5-methylisoquinolin-1(2H)-one | HCID 18369493 | 29% |
Reaction Steps
To a suspension of 0.8 g (5.0 mmol) of 5-methyl-1-isoquinolinone in 30 ml of methylene chloride was added 0.85 (5.3 mmol) of bromine. The resulting orange mixture was stirred at 25° for 18 hours and diluted with 50 ml of ether. The solid was filtered and washed with methanol to give 0.35 g (29%) of product; mp 201°-210°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05177075 |
| Source dataset | uspto-grants-1993_01 |
| ORD ID | ord-9ab914f771d14422979e6d0854d8d22a |
| Source note | uspto-grants-1993_01 |