HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → 1-Chloro-1,1-difluoro-3-phenylpropan-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Acetic acid, 2-chloro-2,2-difluoro-, ethyl ester | HCID 67843 | — |
| Reactant | HCID 178418336 | HCID 178418336 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Chloro-1,1-difluoro-3-phenylpropan-2-one | HCID 13053148 | — |
Reaction Steps
A solution of 20 g of ethyl chlorodifluoroacetate in 150 ml ether was treated with one equivalent of benzyl magnesium chloride in 63 ml THF at -40° C. under nitrogen. After 2 hours, the reaction was poured into aqueous NH4Cl and extracted with ether. Evaporation and distillation (0.1 mm Hg) of the residue gave 24.8 g of an oil which was used directly.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05177111 |
| Source dataset | uspto-grants-1993_01 |
| ORD ID | ord-b041517790a440d7a3b30b38dcc20c57 |
| Source note | uspto-grants-1993_01 |