HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Xylene → HCID 19802911, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Xylene | HCID 7237 | — |
| Reactant | 2-Naphthaleneacetic acid | HCID 11393 | — |
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 2-Propylamino-5-methoxytetralin | HCID 10242548 | — |
| Product | HCID 19802911 | HCID 19802911 | — |
Reaction Steps
A mixture of 2-(N-n-propylamino)-5-methoxytetralin, 2-naphthylacetic acid and trimethylaminoborohydride in dry xylene was refluxed under an atmosphere of nitrogen as described by Horn et al. Pharm. Weekbld. Sci. Ed. 7 208-211, 1985. The resulting methoxy intermediate was demethylated using boron tribromide as described in the above article to yield the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05177112 |
| Source dataset | uspto-grants-1993_01 |
| ORD ID | ord-929376223acf47478e197a572afb5ac0 |
| Source note | uspto-grants-1993_01 |