Methyl alpha-bromo-2-chlorophenylacetate → HCID 19802768, compound

HRID 1645949Notes

Reaction equation

HRID 1645949 reaction equation
[CH2:1]([C:5]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=2)[C:8]([S:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=2)=[N:7][N:6]=1)[CH2:2][CH2:3][CH3:4].Br[CH:28]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=1[Cl:39])[C:29]([O:31]C)=[O:30]>>[CH2:1]([C:5]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH:28]([C:29]([OH:31])=[O:30])[C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=3[Cl:39])=[CH:13][CH:12]=2)[C:8]([S:18][CH2:19][C:20]2[CH:21]=[CH:22][C:23]([Cl:26])=[CH:24][CH:25]=2)=[N:7][N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 10730282Methyl alpha-bromo-2-chlorophenylacetateHCID 19802729HCID 19802729, compound

Product 1

HCID 19802768HCID 19802768, compoundYield 75%

Procedure

Reaction of 3-butyl-5-(4-chlorobenzylthio)-4-(4-hydroxybenzyl)-4H-1,2,4-triazole (from Example 5, Step A) with methyl 2-bromo-2-(2-chlorophenyl)acetate, from Step A, according to the procedure of Example 5, Step B, provided a 75% yield of the title compound as a glass; homogeneous by TLC in 97:3 C2Cl2 -MeOH.

Sources & evidence

ORD record
ord-7724bb14039f43ee97cd52d3ae0c96fb
Source dataset
uspto-grants-1993_01
Patent number
US05177095

Reaction notes

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