Chloroform → HCID 19802764, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 43.2 mg (0.175 mmol) of ethyl valerate benzoylhydrazone (from Step K) in 0.2 ml of ethanol was added a solution of 82 mg (0.262 mmol) of methyl 2-(4-aminomethyl-2-propylphenoxy)-2-phenylacetate (from Step J) in 0.2 ml of ethanol. The resulting solution was stirred under N2 at 50° C. for 5.5 hours. After dilution with 0.4 ml of ethanol, the solution was then stirred at 70° C. under a condenser for 13 hours. Next, the solution was co-evaporated with CHCl3. The residue was chromatographed twice in silica gel columns (gradient elution, first with 0.5-3% and then with 0.3-2% MeOH in CHCl2) to give 32 mg (37%) of the title compound as a white glass; homogeneous by TLC in 9:1 CH2Cl2 -MeOH.

Provenance & Evidence