Sodium Methoxide → HCID 13020163, compound

Participants

Reaction Steps

1-(2',3',5'-Tri-O-benzoyl-α-D-arabinofuranosyl)thymine (18.6 g, 32.6 mmol) was dissolved in dry methanol and adjusted to pH 11 (as indicated by moist pH test paper) with freshly prepared sodium methoxide. After being stirred overnight, the solution was treated with Dowex-50 H+ resin, filtered, and evaporated to dryness. The residue was washed with ethyl acetate and dried, giving a crude yield of 8.0 g (69%). This was used without further purification. Its identity as Compound II was established by the following:

Provenance & Evidence